一、个人简介
李烈，青年学者，副教授，2023年毕业于湖南大学化员工物传感与计量学国家重点实验室，获生物学博士学位，同年入职三亿体育官网。目前主持山东省自然科学基金青年项目，并以第一作者身份发表SCI论文9篇，包括CCS Chemistry，Analytical Chemistry，Nano Today，Chemical Engineering Journal，Chinese Chemical Letters、Talanta等国内外高水平期刊。
二、研究方向
主要从事肿瘤的精准诊断与治疗研究：
1． 结合功能核酸和DNA纳米技术，发展智能高效、安全可靠的功能化DNA纳米诊疗探针
2． 以特定细胞器为研究对象，开发基于自组装DNA纳米结构的细胞器调控工具，实现细胞行为的精准调控
三、项目研究成果、获奖及荣誉
1. Lie Li, Haiyan Chen, Xiaohong Wen, Suping Li, Mei Yang, Qiuping Guo*, Kemin Wang*. A Dual Endogenous Stimuli-Responsive Framework Nucleic Acid Nanodevice for MicroRNA Imaging. CCS Chemistry, 2023, 5, 2403-2414.
2. Lie Li, Yazhou Ren, Xiaohong Wen, Qiuping Guo*, Jie Wang, Suping Li, Mei Yang, Kemin Wang*. Endogenous miRNA-Activated DNA Nanomachine for Intracellular miRNA Imaging and Gene Silencing. Analytical Chemistry, 2021, 93, 13919-13927.
3. Lie Li1, Jun Wan1, Xiaohong Wen, Qiuping Guo*, Huishan Jiang, Jie Wang, Yazhou Ren, Kemin Wang*. Identification of a New DNA Aptamer by Tissue-SELEX for Cancer Recognition and Imaging. Analytical Chemistry, 2021, 93, 7369-7377.
4. Lie Li1, Jie Wang1, Huishan Jiang, Xiaohong Wen, Mei Yang, Suping Li, Qiuping Guo*, Kemin Wang*. DNA Tetrahedron-Based Split Aptamer Probes for Reliable Imaging of ATP in Living Cells. Chinese Chemical Letters, 2023, 34, 107506.
5. Lie Li1, Suping Li1, Jie Wang, Xiaohong Wen, Mei Yang, Haiyan Chen, Qiuping Guo*, Kemin Wang*. Extracellular ATP-Activated Hybridization Chain Reaction for Accurate and Sensitive Detection of Cancer Cells. Chinese Chemical Letters, 2023, 34, 108399.
6. Lie Li, Huishan Jiang, Xiangxian Meng, Xiaohong Wen, Qiuping Guo*, Zenghui Li, Jie Wang, Yazhou Ren, Kemin Wang*. Highly Sensitive Detection of Cancer Cells via Split Aptamer Mediated Proximity-Induced Hybridization Chain Reaction. Talanta, 2021, 223, 121724.
7. Lie Li, Shuo Xu, Mingxuan Chen, Peifen Lu, Yu Wang, Chang Liu, Jianwei Jiao*, Peng Miao*, Jin Jiao*. A Hierarchically Programmable DNA Nanodevice for Spatiotemporally Selective Imaging of Mitochondrial MicroRNA in Cells and Animals. Nano Today, 2025, 64, 102779.
8. Lie Li1, Shuo Xu1, Mingxuan Chen, Peifen Lu, Miaoqing Zhao*, Jianwei Jiao*, Jin Jiao*. An Endogenous Enzyme-Gated DNA Nanomachine for Spatially Controlled Imaging of Intracellular MicroRNA and In Situ Evaluation of Drug Response. Chemical Engineering Journal, 2025, 505, 159310.
9. Shuo Xu1, Lie Li1, Noshin Afshan, Gang Wang, Miaoqing Zhao*, Jianwei Jiao*, Jin Jiao*. Self-Consuming DNA Nanogear Retrieval Exosomes for Grading Analysis of Gliomas. Chemical Engineering Journal, 2024, 485, 150143.
四、联系方式（用于网页展示 自愿）
lilie@sdfmu.edu.cn
